2022-01 Tracking the Epigenetic and Genetic Evolution of Instability via Population Dynamics

Project Description

Questions:

1.What are the dynamics of instability?
•Do clones gradually lose production?
•Or do clones lose productivity in a stochastic manner?
•How does this behavior differ between stable and unstable lines?
These insights would help illuminate mechanisms of instability
2.How does production level affect stability?
•Is production uniformly anticorrelated with stability at a clonal level?
•Are there regimes of production that are stable?
These insights will illuminate strategies to minimize instability or maximize production without incurring instability

Solution: Simultaneously characterize subclonal dynamics and production levels within stable and unstable CHO producer lines

Project Pitch

KalhorBetenbaugh-Pitch-v4-mjbkr


Project Leaders Reza Kalhor; Michael Betenbaugh
Lead Student Chris Haoyu Cao Kent Rapp
University Johns Hopkins University

Mentor Meetings

2022-01 : 07/30/2025 Mentor Meeting

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2022-01 : 05/07/2025 Mentor Meeting

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2022-01 : 10/23/2024 Mentor Meeting

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2022-01 : 09/11/2024 Mentor Meeting

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2022-01 : 07/10/2024 Mentor Meeting

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2022-01 : 04/24/2024 Mentor Meeting

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2022-01 : 02/26/2024 Mentor Meeting

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2022-01 : 12/13/2023 Mentor Meeting

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2022-01 : 10/25/2023 Mentor Meeting

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2022-01 : 03/17/2023 Mentor Meeting

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2022-01 : 09/17/2023 Mentor Meeting

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2022-01 : 07/26/2023 Mentor Meeting

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2022-01 : 05/31/2023 Mentor Meeting

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