Funded Project Updates – Virtual Posters
Introductions
Dr. Mike Betenbaugh
Group 1
Mechanistic-informed Hybrid Models for CHO Fed-Batch and Perfusion Nutrient Control
Presenter: Pratik Khare
Elucidating Translation Bottlenecks Through Ribosome Profiling Methods
Presenter: Kent Rapp
Enhancing Media Stability Predictions by Kinetic and Thermodynamic Modeling
Presenter: Tianxin Zhang
Controlling Citric Acid Cycle Activity and Cellular Redox State for Improved Productivity
Presenter: Bradley Priem
Constructing Antifouling Membrane Filtration Systems for Continuous Harvesting
Presenter: Boran Sun
Exploring Alternative Mammalian Hosts for Adeno-Associated Virus Production
Presenters: SoYoung Park (UML) and Kevin Wen (JHU)
Bioelectronic Sensors for Rapid Assessment of Antibody Titer and Glycan Structure
Presenters: Dana Motabar and Chen-Yu Chen
Nutrient Concentrates: Experiments and Modeling Media Formulations for Process Intensification
Presenter: Tianxin Zhang
Enhancing Predictions of Media Solubility and Stability: Incorporating Chemical-Complexation and Hydrogen-Bonding Effects
Presenter: Tianxin Zhang
Integrating Single Cell Sequencing and ATAC Sew Analysis for Deciphering Cell Line Evolution
Presenter: Kevin McFarland
Group 2
Advanced Manufacturing Platform for Adeno-Associated Virus (AAV) Production
Presenter: Dr. David McNally
Dipeptides in CHO Culture: Elucidating Uptake Kinetics, Metabolism, and Enhanced Solubility
Presenter: Pranay Ladiwala
Enhancing Stability in CHO Cells: The Linkages Between Culture Stress, Chromatin, and Gene Expression
Presenter: Dylan Chitwood
Establishing Markers for Stability and a Model for Accelerated Prediction of Production (In)stability
Presenter: Lauren Cordova
Metal Speciation in AMBIC Media
Presenter: Sarah Wysor
Metal Speciation in Cultures: Impact on Growth, Productivity, and Quality
Presenter: Lateef Aliyu
Redox Speciation and Electrochemical Probing in AMBIC Media
Presenters: Dana Motabar (UMD) and Junxi Lai (JHU)
Transcriptomic Studies Coupled with Medium Optimization to Address the Bottleneck in the Cellular Physiology for AAV Production
Presenter: Yongdan Wang
[video src="https://www.ambic.org/wp-content/uploads/2022/01/Transcriptomic-studies-coupled-with-medium-optimization-to-address-the-bottleneck-in-the-cellular-physiology-for-AAV-production.mp4" /]