Current Projects

Project TitleStart Date
2022-02-01
2022-02-01
2022-02-01
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2022-02-01
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2022-02-01
2022-02-01
2021-02-01
2021-01-14
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2020-06-01
2020-01-01
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2022-01 Tracking the Epigenetic and Genetic Evolution of Instability via Population Dynamics0000-00-00
2022-04 Develop an Inducible Stable Producer Cell Line for rAAV Production via Site-specific Integration0000-00-00
2022-06 Dissecting spent media to elucidate components and mechanisms that affect cell culture performance0000-00-00
2022-07 Comprehensive Metals Mass Balance in CHO Cell Processes0000-00-00
2022-08 Maximizing Yields of AAV and Elucidating the Role of Media Components Through Design and Optimization of AMBIC.293 Media0000-00-00
2022-21 Deep learning-powered in situ bioprocess monitoring with Raman spectroscopy0000-00-00
2022-23 A sensing and switchable cell line toggles between proliferation and production modes0000-00-00
Controlling and applying the lactate shift for bioprocess monitoring and bioproduction improvements0000-00-00
F1 Elucidating Concentrated Media Component Bucketing Strategies and Order of Addition for Process Intensification0000-00-00
S2 Non-invasive classification and selection of CHO cells0000-00-00
S5 The feasibility of emerging non-CRISPR gene editing platforms for CHO cell engineering0000-00-00
S6 Ultrasensitive, Rapid Assessment of AAV Quality - including Empty & Full0000-00-00
S7 An Electrochemical Sensor for Rapid, High Sensitivity Detection of Vitamins and Degradation Products in Cell Culture Media0000-00-00

Over the past two decades, the biopharmaceutical industry has emerged as one of the major manufacturing industries of growth in the US and around the world. Biomanufacturing represents nearly 2% of the total US GDP (Carlson, 2011) and its fraction is growing (Glaser, 2013). Much of biomanufacturing involves the application of mammalian cells, especially Chinese hamster ovary (CHO) cells, to produce therapeutic proteins and other biologics, i.e. biopharmaceuticals. Our biomanufacturing research will focus on the upstream development of cell lines and production processes.

With the advent of wealth of new biological information brought about in large part through the revolutions in ‘omics and data quality, and manufacturing efficiencies. These changes provide an abundance of precompetitive research challenges for the biomanufacturing community in the upstream area to realize a future where biological knowledge can be harnessed to produce biologics more efficiently and effectively in a reliable and standardized framework.

Follow the current project links the see what we’ve been up to, or click the button below to see projects we’ve already completed!