Current Projects
| Project Title | Start Date |
|---|---|
| Towards a Multi-dimensional NISTCHO Reference Annotation for the AMBIC Community | 2024-11-19 |
| 2022-02-01 | |
| 2022-02-01 | |
| 2022-02-01 | |
| 2022-02-01 | |
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| 2022-02-01 | |
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| 2022-02-01 | |
| 2022-02-01 | |
| 2021-02-01 | |
| 2021-01-14 | |
| 2021-01-01 | |
| 2021-01-01 | |
| 2021-01-01 | |
| 2021-01-01 | |
| 2021-01-01 | |
| 2021-01-01 | |
| 2020-06-01 | |
| 2020-01-01 | |
| 0000-00-00 | |
| 2022-01 Tracking the Epigenetic and Genetic Evolution of Instability via Population Dynamics | 0000-00-00 |
| 2022-04 Develop an Inducible Stable Producer Cell Line for rAAV Production via Site-specific Integration | 0000-00-00 |
| 2022-06 Dissecting spent media to elucidate components and mechanisms that affect cell culture performance | 0000-00-00 |
| 2022-07 Comprehensive Metals Mass Balance in CHO Cell Processes | 0000-00-00 |
| 2022-08 Maximizing Yields of AAV and Elucidating the Role of Media Components Through Design and Optimization of AMBIC.293 Media | 0000-00-00 |
| 2022-21 Deep learning-powered in situ bioprocess monitoring with Raman spectroscopy | 0000-00-00 |
| 2022-23 A sensing and switchable cell line toggles between proliferation and production modes | 0000-00-00 |
| Advanced PAT Sensor for Rapid, High Sensitivity Detection and Control of Dipeptides and Bitamins in Cell Culture Media | 0000-00-00 |
| Characterization of Upstream Process parameters and Cell Culture Additives Impact on AAV Quality Attributes | 0000-00-00 |
| Controlling and applying the lactate shift for bioprocess monitoring and bioproduction improvements | 0000-00-00 |
| Enhancer Additives and Protector Peptides for improving CHO Cell Productivity and Product Quality Attributes | 0000-00-00 |
| F1 Elucidating Concentrated Media Component Bucketing Strategies and Order of Addition for Process Intensification | 0000-00-00 |
| S2 Non-invasive classification and selection of CHO cells | 0000-00-00 |
| S5 The feasibility of emerging non-CRISPR gene editing platforms for CHO cell engineering | 0000-00-00 |
| S6 Ultrasensitive, Rapid Assessment of AAV Quality - including Empty & Full | 0000-00-00 |
| S7 An Electrochemical Sensor for Rapid, High Sensitivity Detection of Vitamins and Degradation Products in Cell Culture Media | 0000-00-00 |
Over the past two decades, the biopharmaceutical industry has emerged as one of the major manufacturing industries of growth in the US and around the world. Biomanufacturing represents nearly 2% of the total US GDP (Carlson, 2011) and its fraction is growing (Glaser, 2013). Much of biomanufacturing involves the application of mammalian cells, especially Chinese hamster ovary (CHO) cells, to produce therapeutic proteins and other biologics, i.e. biopharmaceuticals. Our biomanufacturing research will focus on the upstream development of cell lines and production processes.
With the advent of wealth of new biological information brought about in large part through the revolutions in ‘omics and data quality, and manufacturing efficiencies. These changes provide an abundance of precompetitive research challenges for the biomanufacturing community in the upstream area to realize a future where biological knowledge can be harnessed to produce biologics more efficiently and effectively in a reliable and standardized framework.
Follow the current project links the see what we’ve been up to, or click the button below to see projects we’ve already completed!